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Pro-Inflammatory Molecules Implicated in Multiple Sclerosis Divert the Development of Human Oligodendrocyte Lineage Cells

20 May 2025

Abstract excerpt

BACKGROUND AND OBJECTIVES: ) on the differentiation of human OPCs. METHODS: and evaluated effects regarding cell viability, expression of OL lineage markers, and coexpression of astrocyte markers. To relate our findings to the molecular properties of OPCs as found in the MS brain, we reanalyzed publicly available single-nuclear RNA sequencing (RNAseq) datasets. RESULTS: decreased the proportion of cells...

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PMID: 40393021
DOI: 10.1212/nxi.0000000000200407

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