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Insights into Aldehyde Dehydrogenase Enzymes: A Structural Perspective

14 May 2021

Abstract excerpt

Aldehyde dehydrogenases engage in many cellular functions, however their dysfunction resulting in accumulation of their substrates can be cytotoxic. ALDHs are responsible for the NAD(P)-dependent oxidation of aldehydes to carboxylic acids, participating in detoxification, biosynthesis, antioxidant and regulatory functions. Severe diseases, including alcohol intolerance, cancer, cardiovascular and neurological...

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PMID: 34055881
DOI: 10.3389/fmolb.2021.659550

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