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Article

Synonymous mutations that regulate translation speed might play a non-negligible role in liver cancer development.

BMC cancer - 9 Apr 2021

Li Qun, Li Jian, Yu Chun-Peng, Chang Shuai, Xie Ling-Ling, Wang Song

Abstract excerpt

BACKGROUND: Synonymous mutations do not change the protein sequences. Automatically, they have been regarded as neutral events and are ignored in the mutation-based cancer studies. However, synonymous mutations will change the codon optimality, resulting in altered translational velocity. METHODS: We fully utilized the transcriptome and translatome of liver cancer and normal tissue from ten patients. We profiled...

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Source

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Identifiers

PMID: 33836673
DOI: 10.1186/s12885-021-08131-w
PMCID: PMC8033552

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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