Article

ALKBH1 drives codon-biased, pro-oncogenic translation and tumor microenvironment remodeling in glioma via tRNA wobble oxidation

2025-12-01

Abstract excerpt

Gliomas rely on translational plasticity to sustain heterogeneity, stemness, and immune evasion. Here we identify the tRNA dioxygenase ALKBH1 as a central regulator of codon-biased translation and tumor microenvironment remodeling. LC-MS/MS profiling of patient tumors revealed enrichment of ALKBH1-mediated wobble cytidine oxidation modifications in high-grade gliomas. Genetic perturbation demonstrated that ALKBH1...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9eadd233-06bc-515f-8213-a43acf6053fa
DOI: 10.1101/2025.11.28.691056

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ALKBH1 drives codon-biased, pro-oncogenic translation and tumor microenvironment remodeling in glioma via tRNA wobble oxidationDOI 10.1101/2025.11.28.691056Read

Third-nucleotide codon bias and synonymous codon bias define functional translational programs that shape human tissue and cancer proteomesSemantic proximity Read

Targeting tRNA-Arg-TCT-4-1 suppresses cancer cell growth and tumorigenesisSemantic proximity Read

Deregulating m6A regulators leads to altered RNA biology in glioma cell linesSemantic proximity Read

Oncogenes have the most distinct codon biases in the genome and codon signatures that oppose tumor suppressor genesSemantic proximity Read

Codon-biased translation can be regulated by wobble-base tRNA modification systems during cellular stress responsesSemantic proximity Read

Screening of targets related to amino acid metabolism in glioma to identify the tumor-promoting effects of its core gene ASLSemantic proximity Read

Dysregulation of tRNA methylation in cancer: Mechanisms and targeting therapeutic strategiesSemantic proximity Read

Translational efficiency across healthy and tumor tissues is proliferation-relatedSemantic proximity Read

IDH1-dependent m6A methylation defines transcriptomic heterogeneity in gliomaSemantic proximity Read

Tumor heterogeneity and tumor-microglia interactions in primary and recurrent IDH1-mutant gliomas.Semantic proximity Read

ADAT2/3-mediated tRNA editing promotes cancer cell growth and tumorigenicitySemantic proximity Read

MtDNA heteroplasmy controls tumor immune reprogramming through mitochondrial translationSemantic proximity Read