Article

Evolutionary analysis of gene ages across TADs associates chromatin topology with whole genome duplications

2021-06-11

Abstract excerpt

<h4>Summary</h4> Topologically associated domains (TADs) are interaction sub-networks of chromosomal regions in 3D genomes. TAD boundaries frequently coincide with genome breaks while boundary deletion is under negative selection, suggesting that TADs may facilitate genome rearrangements and evolution. We show that genes co-localise by evolutionary age in humans and mice, resulting in TADs having different propor...

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Literature Corpus work: d98da65d-43e9-54b4-8539-5b846f51246d
DOI: 10.1101/2021.06.11.448047

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