Article

Functional associations of evolutionarily recent human genes exhibit sensitivity to the 3D genome landscape and disease

2024-03-17

Abstract excerpt

<h4>Summary</h4> Genome organization is intricately tied to regulating genes and associated cell fate decisions. Here, we examine the positioning and functional significance of human genes, grouped by their lineage restriction level, within the 3D organization of the genome. We reveal that genes of different lineage restriction levels have distinct positioning relationships with both domains and loop anchors, and...

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Literature Corpus work: f8dc16b4-1778-55c3-8362-faa353d67df0
DOI: 10.1101/2024.03.17.585403

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