Article

Global chromatin reorganization and regulation of genes with specific evolutionary ages during differentiation and cancer

2023-11-02

Abstract excerpt

Cancer cells are highly plastic, allowing them to adapt to changing conditions. Genes related to basic cellular processes evolved in ancient species, while more specialized genes appeared later with multicellularity (metazoan genes) or even after mammals evolved. Transcriptomic analyses have shown that ancient genes are up-regulated in cancer, while metazoan-origin genes are inactivated. Despite the importance of...

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Literature Corpus work: eb675ab4-ab19-571f-9c9d-9292d5c77b9f
DOI: 10.1101/2023.10.30.564438

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