Article

Evolutionary rewiring of the human regulatory network by waves of genome expansion

2017-07-17

Abstract excerpt

Genome expansion is believed to be an important driver of the evolution of gene regulation. To investigate the role of newly arising sequence in rewiring the regulatory network we estimated the age of each region of the human genome by applying maximum parsimony to genome-wide alignments with 100 vertebrates. We then studied the age distribution of several types of functional regions, with a focus on regulatory el...

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Literature Corpus work: 781409bf-a510-5182-96c2-6776d27579f5
DOI: 10.1101/164434

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