Article

Ancient genomic regulatory blocks are a major source for gene deserts in vertebrates after whole genome duplications

2019-09-25

Abstract excerpt

We investigated how the two rounds of whole genome duplication that occurred at the base of the vertebrate lineage have impacted ancient microsyntenic associations involving developmental regulators (known as genomic regulatory blocks, GRBs). We showed that the majority of GRBs present in the last common ancestor of chordates have been maintained as a single copy in humans. We found evidence that dismantling of th...

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Literature Corpus work: 5e0afa90-3563-56bf-9d92-ac95ba2cf5a7
DOI: 10.1101/776369

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