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Article

DNA lesion bypass and the stochastic dynamics of transcription-coupled repair.

Proceedings of the National Academy of Sciences of the United States of America - 14 May 2024

Nicholson Michael D, Anderson Craig J, Odom Duncan T, Aitken Sarah J, Taylor Martin S

Abstract excerpt

DNA base damage is a major source of oncogenic mutations and disruption to gene expression. The stalling of RNA polymerase II (RNAP) at sites of DNA damage and the subsequent triggering of repair processes have major roles in shaping the genome-wide distribution of mutations, clearing barriers to transcription, and minimizing the production of miscoded gene products. Despite its importance for genetic integrity,...

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Identifiers

PMID: 38717857
DOI: 10.1073/pnas.2403871121
PMCID: PMC11098089

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