Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An in silico model of LINE-1-mediated neoplastic evolution.

Bioinformatics (Oxford, England) - 15 Aug 2020

LeBien Jack, McCollam Gerald, Atallah Joel

Abstract excerpt

MOTIVATION: Recent research has uncovered roles for transposable elements (TEs) in multiple evolutionary processes, ranging from somatic evolution in cancer to putatively adaptive germline evolution across species. Most models of TE population dynamics, however, have not incorporated actual genome sequence data. The effect of site integration preferences of specific TEs on evolutionary outcomes and the effects of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Computer Simulation
Share to DNA Transposable Elements

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Evolution, Molecular

Share to Long Interspersed Nucleotide Elements

Source

Identifiers

PMID: 32365170
DOI: 10.1093/bioinformatics/btaa279

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An in silico model of LINE-1-mediated neoplastic evolution.PMID 32365170Read ↗

Landscape of somatic retrotransposition in human cancers.Semantic proximity Read ↗

Mechanism-guided quantification of LINE-1 reveals p53 regulation of both retrotransposition and transcriptionSemantic proximity Read ↗

Pan-cancer analysis of whole genomes reveals driver rearrangements promoted by LINE-1 retrotransposition in human tumoursSemantic proximity Read ↗

Synchronous L1 retrotransposition events promote chromosomal crossover early in human tumorigenesisSemantic proximity Read ↗

Extensive mosaicism by somatic L1 retrotransposition in normal human cellsSemantic proximity Read ↗

The Influence of LINE-1 and SINE Retrotransposons on Mammalian Genomes.Semantic proximity Read ↗

L1 Retrotransposon Heterogeneity in Ovarian Tumor Cell Evolution.Semantic proximity Read ↗

p53 restoration suppresses retrotransposon-driven chromosomal instability through nonlinear let-7 feedback and stochastic burst controlSemantic proximity Read ↗

The insertional history of an active family of L1 retrotransposons in humans.Semantic proximity Read ↗

Recent Non-LTR Retrotransposon Activity Predicts Cancer Prevalence in MammalsSemantic proximity Read ↗

Comprehensive Scanning Mutagenesis of Human Retrotransposon LINE-1 Identifies Motifs Essential for Function.Semantic proximity Read ↗

Evolutionary insights from profiling LINE-1 activity at allelic resolution in a single human genomeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.