Article
JAK2 signalling to HNRNPA1 represses retrotransposon activity in haematopoietic stem cells
2025-07-09
Abstract excerpt
Retrotransposon expression must be tightly controlled, particularly in long-lived multipotent stem cells, to prevent deleterious consequences including insertional mutations. Several mechanisms are known to repress retrotransposon transcription during development which are generally thought to persist thereafter. However, integration of retrotransposable elements into host genomes has also provided a major source...
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Identifiers and source
- Literature Corpus work
- aeda88b1-2e00-5c67-8c98-b47deef4529d
- DOI
- 10.1101/2025.07.07.663405