Article

Comprehensive transcription factor perturbations recapitulate fibroblast transcriptional states

2024-08-03

Abstract excerpt

<h4>Summary</h4> Cell atlas projects have nominated recurrent transcriptional states as drivers of biological processes and disease, but their origins, regulation, and properties remain unclear. To enable complementary functional studies, we developed a scalable approach for recapitulating cell states in vitro using CRISPR activation (CRISPRa) Perturb-seq. Aided by a novel multiplexing method, we activated 1,836...

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Literature Corpus work: 62a56422-363a-52b7-8525-8fe950ea47e1
DOI: 10.1101/2024.07.31.606073

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