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Spindle Microtubule Dysfunction and Cancer Predisposition

6 Jun 2014

Abstract excerpt

Chromosome segregation and spindle microtubule dynamics are strictly coordinated during cell division in order to preserve genomic integrity. Alterations in the genome that affect microtubule stability and spindle assembly during mitosis may contribute to genomic instability and cancer predisposition, but directly testing this potential link poses a significant challenge. Germ-line mutations in tumor suppressor...

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PMID: 24905602
DOI: 10.1002/jcp.24691

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