Article

Molecular landscape and functional characterization of centrosome amplification in ovarian cancer

2022-09-15

Abstract excerpt

High grade serous ovarian carcinoma (HGSOC) is characterised by poor outcome and extreme chromosome instability (CIN). Therapies targeting centrosome amplification (CA), a key mediator of chromosome missegregation and CIN, may have significant clinical utility in HGSOC. However, the prevalence of CA in HGSOC, its relationship to genomic biomarkers of CIN and its potential impact on therapeutic response have not be...

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Literature Corpus work: d7fe0130-a663-534a-86b6-f81969050250
DOI: 10.1101/2022.09.13.507750

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