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Molecular landscape and functional characterization of centrosome amplification in ovarian cancer

16 Oct 2023

Abstract excerpt

High-grade serous ovarian carcinoma (HGSOC) is characterised by poor outcome and extreme chromosome instability (CIN). Therapies targeting centrosome amplification (CA), a key mediator of chromosome missegregation, may have significant clinical utility in HGSOC. However, the prevalence of CA in HGSOC, its relationship to genomic biomarkers of CIN and its potential impact on therapeutic response have not been...

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PMID: 37845213
DOI: 10.1038/s41467-023-41840-3

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