Article

The RZZ complex integrates spindle checkpoint maintenance with dynamic expansion of unattached kinetochores

2018-04-09

Abstract excerpt

<h4>Summary</h4> The Mad1-Mad2 heterodimer is the catalytic hub of the spindle assembly checkpoint (SAC), which controls mitosis through assembly of a multi-subunit anaphase inhibitor, the mitotic checkpoint complex (MCC) [1, 2]. Mad1-Mad2 first catalyzes MCC assembly at interphase nuclear pores [3], then migrates to kinetochores at nuclear envelope breakdown (NEBD) and resumes MCC assembly until bipolar spindle...

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Literature Corpus work: 4233f7a8-3d9a-5b63-b706-dde6c3c76cdc
DOI: 10.1101/297580

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