Article

Mechanisms of Chromosomal Instability in High-grade Serous Ovarian Carcinoma

2019-08-06

Abstract excerpt

Chromosomal instability (CIN), the continual gain and loss of chromosomes or parts of chromosomes, occurs in the majority of cancers and confers poor prognosis. Mechanisms driving CIN remain unknown in most cancer types due to a scarcity of functional studies. High-grade serous ovarian carcinoma (HGSC), the most common subtype of ovarian cancer, is the major cause of death due to gynaecological malignancy in the W...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 985ce886-707e-5f66-8a3a-a5e5874eca7b
DOI: 10.1101/727537

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mechanisms of Chromosomal Instability in High-grade Serous Ovarian CarcinomaDOI 10.1101/727537Read

Specific Mechanisms of Chromosomal Instability Indicate Therapeutic Sensitivities in High-Grade Serous Ovarian CarcinomaSemantic proximity Read

Chromosome instability is prevalent and dynamic in high-grade serous ovarian cancer patient samplesSemantic proximity Read

Molecular landscape and functional characterization of centrosome amplification in ovarian cancerSemantic proximity Read

A survey of CIN measures across mechanistic modelsSemantic proximity Read

Exploiting a living biobank to delineate mechanisms underlying disease-specific chromosome instabilitySemantic proximity Read

Molecular landscape and functional characterization of centrosome amplification in ovarian cancerSemantic proximity Read

<i>TP53</i> loss initiates chromosomal instability in high-grade serous ovarian cancerSemantic proximity Read

Signatures of chromosomal instability in human cancersSemantic proximity Read

Reduced SKP1 and CUL1 expression underlies increases in Cyclin E1 and chromosome instability in cellular precursors of high-grade serous ovarian cancerSemantic proximity Read

A living biobank of ovarian cancer ex vivo models reveals profound mitotic heterogeneity.Semantic proximity Read

The temporal dynamics of chromosome instability in ovarian cancer cell lines and primary patient samplesSemantic proximity Read

Unraveling pathologies underlying chromosomal instability in cancers.Semantic proximity Read