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Article

Protein kinase C zeta suppresses low- or high-grade colorectal cancer (CRC) phenotypes by interphase centrosome anchoring.

The Journal of pathology - 1 Apr 2018

Deevi Ravi Kiran, Javadi Arman, McClements Jane, Vohhodina Jekaterina, Savage Kienan, Loughrey Maurice Bernard, Evergren Emma, Campbell Frederick Charles

Abstract excerpt

Histological grading provides prognostic stratification of colorectal cancer (CRC) by scoring heterogeneous phenotypes. Features of aggressiveness include aberrant mitotic spindle configurations, chromosomal breakage, and bizarre multicellular morphology, but pathobiology is poorly understood. Protein kinase C zeta (PKCz) controls mitotic spindle dynamics, chromosome segregation, and multicellular patterns, but...

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Source

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Identifiers

PMID: 29520890
DOI: 10.1002/path.5035
PMCID: PMC5873423

Genes

NHERF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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