Article

Chromosome 3p deletion leads to extensive genomic alterations in diverse cancers and confers synthetic lethality in uveal melanoma

2026-01-23

Abstract excerpt

<h4>ABSTRACT</h4> Chromosome 3p (chr3p) is frequently deleted in multiple cancers, indicating the presence of shared tumor suppressors. Analysis of genomic alterations in 33 different cancer types implicates the deletion or deleterious mutations of SET-domain-containing 2 ( SETD2 ) at chr3p21 in significantly facilitating the formation of isochromosomes, consisting of two identical mirror-imaged arms, thereby pr...

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Literature Corpus work: 6fea33e9-b423-51e0-8ee9-f85553474999
DOI: 10.64898/2026.01.21.700826

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