Article

Clonal effects of the <i>Ras</i> oncogene revealed by somatic mutagenesis in a <i>Drosophila</i> cancer model

2025-05-10

Abstract excerpt

Somatic mutations of Ras , encoding a small GTPase, are detected in a wide range of human cancers. Tumor genome sequencing further reveals a cancer type-dependent mutational spectrum for the Ras gene, suggesting that tissue- and allele-specific effects underlie tumorigenic activity. Although biochemical studies have characterized the GTPase activity of several Ras variants in vitro , precisely how somatic mutat...

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Literature Corpus work: d949b4fa-9119-5865-9491-c0026eb4c8f6
DOI: 10.1101/2025.05.08.652841

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