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Article

Conserved mechanisms of tumorigenesis in the Drosophila adult midgut.

PloS one - 1 Jan 2014

Martorell Òscar, Merlos-Suárez Anna, Campbell Kyra, Barriga Francisco M, Christov Christo P, Miguel-Aliaga Irene, Batlle Eduard, Casanova Jordi, Casali Andreu

Abstract excerpt

Whereas the series of genetic events leading to colorectal cancer (CRC) have been well established, the precise functions that these alterations play in tumor progression and how they disrupt intestinal homeostasis remain poorly characterized. Activation of the Wnt/Wg signaling pathway by a mutation in the gene APC is the most common trigger for CRC, inducing benign lesions that progress to carcinomas due to the...

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Identifiers

PMID: 24516653
DOI: 10.1371/journal.pone.0088413
PMCID: PMC3916428

Genes

APC

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