Article

Signaling by Ras <sup>G12V</sup> depends on EGFR activity <i>in vivo</i>

2025-11-13

Abstract excerpt

Ras proteins are key regulators of signaling pathways initiated by transmembrane tyrosine kinase receptors, and activating Ras mutations are drivers in cancer and RASophaties. The development of effective therapies against these diseases requires a profound understanding of how Ras mutations modify pathway output and interact with other pathway components. In this work we generated G12V activating mutations in the...

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Literature Corpus work: dff36a53-5a02-535c-a832-71e867af3219
DOI: 10.1101/2025.11.12.687982

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