Article

Cancer modeling in colorectal organoids reveals intrinsic differences between oncogenic <i>RAS</i> and <i>BRAF</i> variants

2019-11-29

Abstract excerpt

Colorectal cancers (CRCs) with oncogenic mutations in RAS and BRAF are associated with anti-EGFR therapy resistance. Consequently, all RAS mutant CRC patients are being excluded from this therapy. However, heterogeneity in drug response has been reported between RAS mutant CRC patients. It is poorly understood to what extent such differences are derived from different genetic backgrounds or intrinsic difference...

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Literature Corpus work: 53c76ad5-2439-5736-95b0-c0ebfb7bc219
DOI: 10.1101/860122

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