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Article

Frequent Somatic Mutation in Adult Intestinal Stem Cells Drives Neoplasia and Genetic Mosaicism during Aging.

Cell stem cell - 3 Dec 2015

Siudeja Katarzyna, Nassari Sonya, Gervais Louis, Skorski Patricia, Lameiras Sonia, Stolfa Donato, Zande Maria, Bernard Virginie, Frio Thomas Rio, Bardin Allison J

Abstract excerpt

Adult stem cells may acquire mutations that modify cellular behavior, leading to functional declines in homeostasis or providing a competitive advantage resulting in premalignancy. However, the frequency, phenotypic impact, and mechanisms underlying spontaneous mutagenesis during aging are unclear. Here, we report two mechanisms of genome instability in adult Drosophila intestinal stem cells (ISCs) that cause...

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Identifiers

PMID: 26607382
DOI: 10.1016/j.stem.2015.09.016
PMCID: PMC5138153

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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