Article

Precancer: Mutant clones in normal epithelium outcompete and eliminate esophageal micro-tumors

2021-06-25

Abstract excerpt

<h4>Summary</h4> Human epithelial tissues accumulate cancer-driver mutations with age 1–7 , yet tumor formation remains rare. The positive selection of these mutations argues they alter the behavior and fitness of proliferating cells 8–10 . Hence, normal adult tissues become a patchwork of mutant clones competing for space and survival, with the fittest clones expanding by eliminating their less-competitive nei...

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Literature Corpus work: 87cbc72a-605e-52d3-89d4-83386c19fab5
DOI: 10.1101/2021.06.25.449880

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