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Article

Loss of PI3Kδ activity drives autoimmune colitis by impairing extrathymic Treg differentiation

2024-11-21

Abstract excerpt

Peripherally-derived regulatory T cells (pTregs) have a prominent role in maintaining intestinal immune homeostasis. In cases of phosphoinositide-3-kinase δ (PI3Kδ) inactivation, such as in patients receiving PI3Kδ inhibitor idelalisib as a cancer treatment, breakdown of intestinal immune tolerance occurs frequently in the form of diarrhoea and colon inflammation. In a mouse model of systemic PI3Kδ inactivation, b...

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Identifiers and source

Literature Corpus work
d93fcd2e-bbd8-5142-bb5f-dce7e18ef0ea
DOI
10.1101/2024.11.21.624633
Open publication

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Loss of PI3Kδ activity drives autoimmune colitis by impairing extrathymic Treg differentiationDOI 10.1101/2024.11.21.624633
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