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Article

The role of dysregulated PI3Kdelta signaling in human autoimmunity*

28 Jan 2022

Abstract excerpt

Better treatment of autoimmune diseases requires an improved understanding of the cellular and molecular mechanisms that lead to the breakdown of immune tolerance. The discovery of individuals with germline mutations in PIK3CD (which encodes the p110δ catalytic subunit of PI3K) has revealed the importance of regulated PI3Kδ activity to maintain tolerance. These patients display a range of symptoms including both...

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PMID: 35092042
DOI: 10.1111/imr.13067

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