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Article

CD4+ T Lymphocyte Ablation Prevents Pancreatic Carcinogenesis in Mice

11 Feb 2014

Abstract excerpt

Pancreatic cancer, one of the deadliest human malignancies, is associated with oncogenic Kras and is most commonly preceded by precursor lesions known as pancreatic intraepithelial neoplasias (PanIN). PanIN formation is accompanied by the establishment of an immunotolerant microenvironment. However, the immune contribution to the initiation of pancreatic cancer is currently poorly understood. Here, we genetically...

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PMID: 24795355
DOI: 10.1158/2326-6066.cir-14-0016-t

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