Article
Homeostatic and pathogenic roles of PI3Kδ in the human immune system.
Advances in immunology - 1 Jan 2020
Sogkas Georgios, Adriawan Ignatius Ryan, Dubrowinskaja Natalia, Atschekzei Faranaz, Schmidt Reinhold Ernst
Abstract excerpt
Phosphoinositide 3-kinase delta (PI3Kδ) mediates signaling transduction downstream of diverse immune receptors, including the T cell receptor (TCR), the B cell receptor (BCR), costimulatory molecules and cytokine receptors. Our understanding of the role of PI3Kδ in the immune system comes primarily from mice, and especially from the consequences of pharmacological inhibition of PI3Kδ in mouse models of human...
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