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Article

Gut-microbiota-microglia-brain interactions in Alzheimer's disease: knowledge-based, multi-dimensional characterization.

Alzheimer's research & therapy - 20 Oct 2021

Wang QuanQiu, Davis Pamela B, Qi Xin, Chen Shu G, Gurney Mark E, Perry George, Doraiswamy P Murali, Xu Rong

Abstract excerpt

BACKGROUND: Interactions between the gut microbiota, microglia, and aging may modulate Alzheimer's disease (AD) pathogenesis but the precise nature of such interactions is not known. METHODS: We developed an integrated multi-dimensional, knowledge-driven, systems approach to identify interactions among microbial metabolites, microglia, and AD. Publicly available datasets were repurposed to create a...

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Identifiers

PMID: 34670619
DOI: 10.1186/s13195-021-00917-1
PMCID: PMC8529734

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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