Article
The structure of the N-terminal domain of the product of the lissencephaly gene Lis1 and its functional implications.
Structure (London, England : 1993) - 1 Jun 2004
Kim Myung Hee, Cooper David R, Oleksy Arkadiusz, Devedjiev Yancho, Derewenda Urszula, Reiner Orly, Otlewski Jacek, Derewenda Zygmunt S
Abstract excerpt
Mutations in the Lis1 gene result in lissencephaly (smooth brain), a debilitating developmental syndrome caused by the impaired ability of postmitotic neurons to migrate to their correct destination in the cerebral cortex. Sequence similarities suggest that the LIS1 protein contains a C-terminal seven-blade beta-propeller domain, while the structure of the N-terminal fragment includes the LisH (Lis-homology)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.