Article

LRRK2-I1371V Disrupts Astrocyte Membrane Homeostasis and Paradoxically Enhances α-Synuclein Toxicity Despite Impaired Clearance

2026-02-25

Abstract excerpt

<title>Abstract</title> <p>Astrocyte dysfunction represents a critical pathogenic mechanism in neurodegenerative diseases, particularly through impaired α-synuclein aggregate clearance and aberrant inflammatory responses. Using human iPSC-derived astrocytes carrying the LRRK2-I1371V Parkinson's disease mutation and LRRK2-I1371V-transfected U87-cells, we assessed comprehensive membrane analysis using anisotropy me...

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Literature Corpus work: 655bb84f-6130-5493-9f67-9c9c8dceb2b8
DOI: 10.21203/rs.3.rs-7255076/v1

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