Article

GSAP Regulates Amyloid Beta Production through Modulation of Amyloid Precursor Protein Trafficking

2020-11-13

Abstract excerpt

In addition to participating in γ-secretase activity, presenilin 1 (PS1) regulates trafficking and subcellular localization of β-amyloid precursor protein (APP). We previously showed that gamma-secretase activating protein (GSAP) selectively modulates γ-secretase activity by inducing conformational change in PS1. However, little is known whether and how GSAP might influence APP trafficking and consequent generatio...

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Literature Corpus work: 8c617c4b-8e12-5ebf-a3c8-efc56f8613c8
DOI: 10.1101/2020.11.12.379313

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