Article

Amyloid beta oligomers modulate neuronal autophagy through the primary cilium

2021-06-02

Abstract excerpt

<h4>ABSTRACT</h4> The major neurodegenerative diseases, like Alzheimer’s disease (AD), accumulate neuropathogenic proteins that compromise autophagic function. In AD, autophagy contributes to intracellular APP processing and amyloid beta (Aβ) generation by mutant presenilin-1 (PS1). However, how extracellular soluble Aβ oligomers (Aβo) impact intracellular autophagy is not well understood. The primary cilium (PC)...

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Literature Corpus work: 2ff14c23-9e04-5372-8815-5712ee419347
DOI: 10.1101/2021.06.02.446758

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