Article

Integration of phased Hi-C and molecular phenotype data to study genetic and epigenetic effects on chromatin looping

2018-06-20

Abstract excerpt

<h4>Summary</h4> While genetic variation at chromatin loops is relevant for human disease, the relationships between loop strength, genetics, gene expression, and epigenetics are unclear. Here, we quantitatively interrogate this relationship using Hi-C and molecular phenotype data across cell types and haplotypes. We find that chromatin loops consistently form across multiple cell types and quantitatively vary in...

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Literature Corpus work: 3f05486f-21ed-5801-a08e-ccc297f4ce4e
DOI: 10.1101/352682

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