Article

A network of small RNAs regulates sporulation initiation in <i>C. difficile</i>

2022-10-17

Abstract excerpt

<h4>ABSTRACT</h4> The obligate anaerobic, enteric pathogen Clostridioides difficile persists in the intestinal tract by forming antibiotic resistant endospores that contribute to relapsing and recurrent infections. Despite the importance of sporulation for C. difficile pathogenesis, environmental cues, and molecular mechanisms regulating sporulation initiation remain ill defined. Here, using RIL-seq to capture...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d8a328d6-ffe3-58f7-8a6c-c47614fd9899
DOI: 10.1101/2022.10.17.512509

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A network of small RNAs regulates sporulation initiation in <i>C. difficile</i>DOI 10.1101/2022.10.17.512509Read

A network of small RNAs regulates sporulation initiation in Clostridioides difficileSemantic proximity Read

An RNA-centric global view of <i>Clostridioides difficile</i> reveals broad activity of Hfq in a clinically important Gram-positive bacteriumSemantic proximity Read

Functional genomics reveals that Clostridium difficile Spo0A coordinates sporulation, virulence and metabolism.Semantic proximity Read

A Conserved Switch Controls Virulence, Sporulation, and Motility in <i>C. difficile</i>Semantic proximity Read

Global analysis of the sporulation pathway of Clostridium difficile.Semantic proximity Read

Pleiotropic role of the RNA chaperone protein Hfq in the human pathogen Clostridium difficile.Semantic proximity Read

An RNA-centric global view of Clostridioides difficile reveals broad activity of Hfq in a clinically important gram-positive bacteriumSemantic proximity Read

Remodeling of RNA-Binding Proteome and RNA-mediated regulation as a new layer of control of sporulationSemantic proximity Read

Spo0A suppresses <i>sin</i> locus expression in <i>Clostridioides difficile</i>Semantic proximity Read

A regulatory protein that represses sporulation in <i>Clostridioides difficile</i>Semantic proximity Read

Predictive regulatory and metabolic network models for systems analysis of <i>Clostridioides difficile</i>Semantic proximity Read

A conserved switch controls virulence, sporulation, and motility in C. difficileSemantic proximity Read