Article
Functional genomics reveals that Clostridium difficile Spo0A coordinates sporulation, virulence and metabolism.
BMC genomics - 25 Feb 2014
Pettit Laura J, Browne Hilary P, Yu Lu, Smits Wiep Klaas, Fagan Robert P, Barquist Lars, Martin Melissa J, Goulding David, Duncan Sylvia H, Flint Harry J, Dougan Gordon, Choudhary Jyoti S, Lawley Trevor D
Abstract excerpt
BACKGROUND: Clostridium difficile is an anaerobic, Gram-positive bacterium that can reside as a commensal within the intestinal microbiota of healthy individuals or cause life-threatening antibiotic-associated diarrhea in immunocompromised hosts. C. difficile can also form highly resistant spores that are excreted facilitating host-to-host transmission. The C. difficile spo0A gene encodes a highly conserved...
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