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Article

A network of small RNAs regulates sporulation initiation in Clostridioides difficile

4 May 2023

Abstract excerpt

The obligate anaerobic, enteric pathogen Clostridioides difficile persists in the intestinal tract by forming antibiotic-resistant endospores that contribute to relapsing and recurrent infections. Despite the importance of sporulation for C. difficile pathogenesis, environmental cues and molecular mechanisms that regulate sporulation initiation remain ill-defined. Here, by using RIL-seq to globally capture the...

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PMID: 37140366
DOI: 10.15252/embj.2022112858

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