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Article

A conserved switch controls virulence, sporulation, and motility in C. difficile

13 May 2024

Abstract excerpt

Spore formation is required for environmental survival and transmission of the human enteropathogenic Clostridioides difficile. In all bacterial spore formers, sporulation is regulated through activation of the master response regulator, Spo0A. However, the factors and mechanisms that directly regulate C. difficile Spo0A activity are not defined. In the well-studied Bacillus species, Spo0A is directly inactivated...

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PMID: 38739653
DOI: 10.1371/journal.ppat.1012224

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