Article

Predictive regulatory and metabolic network models for systems analysis of <i>Clostridioides difficile</i>

2020-09-15

Abstract excerpt

<h4>SUMMARY</h4> Though Clostridioides difficile is among the most studied anaerobes, the interplay of metabolism and regulation that underlies its ability to colonize the human gut is unknown. We have compiled public resources into three models and a portal to support comprehensive systems analysis of C. difficile . First, by leveraging 151 transcriptomes from 11 studies we generated a regulatory model (EGRIN)...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7e267d1e-2ff8-5ca9-9871-e374d6aa0b44
DOI: 10.1101/2020.09.14.297382

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Predictive regulatory and metabolic network models for systems analysis of <i>Clostridioides difficile</i>DOI 10.1101/2020.09.14.297382Read

A curated C. difficile strain 630 metabolic network: prediction of essential targets and inhibitorsSemantic proximity Read

Systems biology approach to functionally assess the Clostridioides difficile pangenome reveals genetic diversity with discriminatory power.Semantic proximity Read

A curated C. difficile strain 630 metabolic network: prediction of essential targets and inhibitorsSemantic proximity Read

Transcriptional Profiling of<i>Clostridium difficile</i>and Caco‐2 Cells during InfectionSemantic proximity Read

<i>Clostridium difficile</i> colonizes alternative nutrient niches during infection across distinct murine gut microbiomesSemantic proximity Read

Dual RNA-seq identifies proteins and pathways modulated during <i>Clostridioides difficile</i> colonisationSemantic proximity Read

<i>Clostridioides difficile</i> -mucus interactions encompass shifts in gene expression, metabolism, and biofilm formationSemantic proximity Read

<i>Clostridioides difficile</i> exploits toxin-mediated inflammation to alter the host nutritional landscape and exclude competitors from the gut microbiotaSemantic proximity Read

An RNA-centric global view of <i>Clostridioides difficile</i> reveals broad activity of Hfq in a clinically important Gram-positive bacteriumSemantic proximity Read

Elucidation of regulatory modes for five two-component systems in <i>Escherichia coli</i> reveals novel relationshipsSemantic proximity Read

Functional genomics reveals that Clostridium difficile Spo0A coordinates sporulation, virulence and metabolism.Semantic proximity Read

Human gut microbiota interactions shape the long-term growth dynamics and evolutionary adaptations of <i>Clostridioides difficile</i>Semantic proximity Read