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Article

Early-in-life neuroanatomical and behavioural trajectories in a triple transgenic model of Alzheimer's disease.

Brain structure & function - 1 Sept 2018

Kong Vincent, Devenyi Gabriel A, Gallino Daniel, Ayranci Gülebru, Germann Jürgen, Rollins Colleen, Chakravarty M Mallar

Abstract excerpt

Animal models of Alzheimer's disease (AD) can be used to determine the progressive neurodegeneration characteristics of AD in vivo using magnetic resonance imaging (MRI). Given the need for therapeutic interventions before the onset of frank AD, it is critical to examine if AD models demonstrate neuroanatomical remodeling in an equivalent preclinical phase. This manuscript examines the trajectories of brain and...

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PMID: 29948190
DOI: 10.1007/s00429-018-1691-4

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