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Article

Imaging genomics discovery of a new risk variant for Alzheimer's disease in the postsynaptic SHARPIN gene.

Human brain mapping - 1 Sept 2020

Soheili-Nezhad Sourena, Jahanshad Neda, Guelfi Sebastian, Khosrowabadi Reza, Saykin Andrew J, Thompson Paul M, Beckmann Christian F, Sprooten Emma, Zarei Mojtaba

Abstract excerpt

Molecular mechanisms underlying Alzheimer's disease (AD) are difficult to investigate, partly because diagnosis lags behind the insidious pathological processes. Therefore, identifying AD neuroimaging markers and their genetic modifiers may help study early mechanisms of neurodegeneration. We aimed to identify brain regions of the highest vulnerability to AD using a data-driven search in the AD Neuroimaging...

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Identifiers

PMID: 32558014
DOI: 10.1002/hbm.25083
PMCID: PMC7416020

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