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Article

O-GlcNAcylation stabilizes OCA-B to sustain humoral immunity

2026-03-05

Abstract excerpt

<title>Abstract</title> <p>Protein O-GlcNAcylation is a nutrient-sensitive post-translational modification implicated in immune regulation, yet its role in humoral immunity is poorly defined. Here we show that O-GlcNAcylation is required for effective antibody production downstream of B-cell activation. Pharmacologic inhibition of O-GlcNAc transferase markedly reduced immunoglobulin secretion across T cell–depend...

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Literature Corpus work
d87fbd89-c12f-55b2-a348-0a1465357ace
DOI
10.21203/rs.3.rs-8924149/v1
Open publication

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O-GlcNAcylation stabilizes OCA-B to sustain humoral immunityDOI 10.21203/rs.3.rs-8924149/v1
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