Article

Multivariate analysis of glycogenes reveals coordinated regulation of immunoglobulin glycosylation in an immortalized human B cell system

2025-10-02

Abstract excerpt

While neutralizing ability has traditionally been considered the most important antibody function, appreciation has grown for Fc-mediated 'extra-neutralizing' functions, which are shaped by IgG glycosylation. However, there remain fundamental questions as to how B lymphocytes induce and regulate antibody glycosylation and thus functional capability. Understanding how transcriptional and cell state regulation shape...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3fba278c-9669-5d1b-ba32-a063cac3c59b
DOI: 10.1101/2025.09.30.679651

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multivariate analysis of glycogenes reveals coordinated regulation of immunoglobulin glycosylation in an immortalized human B cell systemDOI 10.1101/2025.09.30.679651Read

IgG N-glycan Signatures as Potential Diagnostic and Prognostic BiomarkersSemantic proximity Read

Antibody glycosylation in inflammation, disease and vaccinationSemantic proximity Read

Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases.Semantic proximity Read

Decoding the Human Immunoglobulin G-Glycan Repertoire Reveals a Spectrum of Fc-Receptor- and Complement-Mediated-Effector ActivitiesSemantic proximity Read

Single-Cell and Spatial Methods for Multimodal Functional Glycan Profiling in TissuesSemantic proximity Read

Variable domain glycosylation as a marker and modulator of immune responses: Insights into autoimmunity and B-cell malignanciesSemantic proximity Read

Unravelling Immunoglobulin G Fc N-Glycosylation: A Dynamic Marker Potentiating Predictive, Preventive and Personalised MedicineSemantic proximity Read

Immunoglobulin G glycosylation in aging and diseasesSemantic proximity Read

IgA displays site- and subclass-specific glycoform differences despite equal glycoenzyme expressionSemantic proximity Read

High-throughput analysis of immunoglobulin G glycosylationSemantic proximity Read

O-GlcNAcylation stabilizes OCA-B to sustain humoral immunitySemantic proximity Read

An integrated multi-omic single cell atlas to redefine human B cell memorySemantic proximity Read