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Variable domain glycosylation as a marker and modulator of immune responses: Insights into autoimmunity and B-cell malignancies

31 Mar 2025

Abstract excerpt

Glycosylation of antibodies is essential for shaping immune responses, as it contributes significantly to antibody function and diversity. While immunoglobulin G (IgG) Fc glycosylation is well-characterized, variable domain glycosylation (VDG) introduces an additional and less understood layer of complexity. Notably, VDG is associated with rheumatoid arthritis, where disease-specific IgG autoantibodies abundantly...

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PMID: 40158366
DOI: 10.1016/j.smim.2025.101946

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