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Protein O-GlcNAcylation in reproductive biology and the impact of metabolic disease

26 Jun 2025

Abstract excerpt

BACKGROUND: Protein O-GlcNAcylation is a reversible post-translational modification which regulates the function of thousands of proteins to control generic and cell type-specific actions. O-GlcNAc addition and removal downstream of the hexosamine biosynthetic pathway (HBP) is mediated by only two enzymes: O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA), respectively. Crucially, O-GlcNAcylation provides a...

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PMID: 40574323
DOI: 10.1093/humupd/dmaf013

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