Article

The Human Pleiotropic Map of GWAS Associations and Therapeutic Implications

2026-05-01

Abstract excerpt

Genetic support for drug targets substantially increases clinical success rates, establishing genome-wide association studies (GWAS) as central to therapeutic hypothesis generation. However, the same genetic evidence that reveals causal gene–disease relationships simultaneously exposes organism-level safety liabilities—a dimension requiring principled, genome-wide quantification. Here we systematically analyse 100...

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Literature Corpus work: d87a133d-3666-5e72-b5f8-7d44c7a52809
DOI: 10.64898/2026.04.28.721048

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