Article

Functional determinants and evolutionary consequences of pleiotropy in complex and Mendelian traits

2024-11-06

Abstract excerpt

Pleiotropy, a phenomenon of multiple phenotypic effects of the same genetic alteration, is one of the most important features of genotype-to-phenotype networks. Over the last century, biologists have actively debated the prevalence, mechanisms, and consequences of pleiotropy. In this work, we employed data on genotype-to-phenotype associations from the Human Phenotype Ontology and Mouse Genome Database, as well as...

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Literature Corpus work: 1c0833de-1e7c-5cfc-b2c7-89d99404ebd2
DOI: 10.1101/2024.10.28.620594

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