Article

Building The Human Genotype-Phenotype Map to Harness Pleiotropy and Refine Disease Mechanisms

2026-02-20

Abstract excerpt

Mapping the pleiotropic effect of genetic variation on biological processes and complex phenotypes is fundamental to extracting translational insight from genome-wide association studies (GWAS). Here we present The Human Genotype-Phenotype Map (GPMap), a repository of colocalizing genetic associations across 15,997 complex traits and 2.7 million molecular measurements, leveraging common and rare variants and cis...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 46d82a46-ddce-5c5d-bf30-fab6ca40be42
DOI: 10.64898/2026.02.19.26346618

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Building The Human Genotype-Phenotype Map to Harness Pleiotropy and Refine Disease MechanismsDOI 10.64898/2026.02.19.26346618Read

Phenome-wide functional dissection of pleiotropic effects highlights key molecular pathways for human complex traits.Semantic proximity Read

Inferring genetic variant networks by leveraging pleiotropy shows trait relationships drive massive pleiotropy in GWASSemantic proximity Read

Genome-Wide Assessment of Pleiotropy Across >1000 Traits from Global BiobanksSemantic proximity Read

High-definition likelihood inference of genetic colocalization reveals protein biomarkers for human complex diseases.Semantic proximity Read

A global overview of pleiotropy and genetic architecture in complex traitsSemantic proximity Read

Phenome-wide search for pleiotropic loci highlights key genes and molecular pathways for human complex traitsSemantic proximity Read

Progress and promise in understanding the genetic basis of common diseases.Semantic proximity Read

A tissue-level phenome-wide network map of colocalized genes and phenotypes in the UK Biobank.Semantic proximity Read

A tissue-level phenome-wide network map of colocalized genes and phenotypes in the UK BiobankSemantic proximity Read

Genetic and environmental correlations between complex phenotypes differ by race/ethnicity and sexSemantic proximity Read

The Human Pleiotropic Map of GWAS Associations and Therapeutic ImplicationsSemantic proximity Read

Correlations between complex human phenotypes vary by genetic background, gender, and environment.Semantic proximity Read